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Murtadha Al-Shareifi e-Library P1: Trim: 8.375in × 10.875in Top: 0.373in Gutter: 0.664in LWBK915-fm LWW-KodaKimble-educational December 7, 2011 20:13 i Applied Therapeutics The Clinical Use of Drugs T E N T H E D I T I O N Edited By Brian K. Alldredge, PHARMD Professor of Clinical Pharmacy and Associate Dean, Academic Affairs Department of Clinical Pharmacy School of Pharmacy University of California, San Francisco San Francisco, California Robin L. Corelli, PHARMD Professor of Clinical Pharmacy Department of Clinical Pharmacy School of Pharmacy University of California, San Francisco San Francisco, California Michael E.
Ernst, PHARMD, BCPS, FCCP Professor (Clinical) Department of Pharmacy Practice and Science College of Pharmacy Department of Family Medicine Carver College of Medicine The University of Iowa Iowa City, Iowa B. Joseph Guglielmo, PHARMD Professor and Chair TA Oliver Chair in Clinical Pharmacy Department of Clinical Pharmacy School of Pharmacy University of California, San Francisco San Francisco, California Pamala A. Jacobson, PHARMD Associate Professor Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota Minneapolis, Minnesota Wayne A. Kradjan, PHARMD, BCPS Dean Emeritus and Professor Emeritus College of Pharmacy Oregon State University Oregon Health & Science University Corvallis, Oregon Bradley R. Williams, PHARMD, FASCP, CGP Professor of Clinical Pharmacy and Clinical Gerontology Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy Schools of Pharmacy and Gerontology University of Southern California Los Angeles, California Dr. Murtadha Al-Shareifi e-Library P1: Trim: 8.375in × 10.875in Top: 0.373in Gutter: 0.664in LWBK915-fm LWW-KodaKimble-educational December 9, 2011 2:6 Acquisitions Editor: David B. Troy Project Manager: Meredith L.
Brittain Marketing Manager: Joy Fisher-Williams Designer: Doug Smock Compositor: Aptara, Inc. C© 2013, 2009, 2005 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com Tenth Edition All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews.
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Materials appearing in this book prepared by individuals as part of their official duties as U.S. Government employees are not covered by the above-mentioned copyright. Printed in China Library of Congress Cataloging-in-Publication Data Koda-Kimble and Young’s applied therapeutics: the clinical use of drugs.
/edited by Brian K. Applied therapeutics Rev. Of: Applied therapeutics: the clinical use of drugs /edited by Mary Anne Koda-Kimble.
Includes bibliographical references and index. ISBN 978-1-60913-713-7 I. Koda-Kimble, Mary Anne. Alldredge, Brian K. Applied therapeutics. Title: Applied therapeutics. Drug Therapy–methods.
WB 330] 615.5′8–dc631 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings.